منابع مشابه
Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells
In recent years, there has been significant progress in understanding the detailed mechanisms of pancreas development. These studies have in turn influenced research aimed at producing pancreatic islet cells from stem cells. Here, we review recent progress in both of these areas.
متن کاملReprogramming of human exocrine pancreas cells to beta cells.
One of the key promises of regenerative medicine is providing a cure for diabetes. Cell-based therapies are proving their safety and efficiency, but donor beta cell shortages and immunological issues remain major hurdles. Reprogramming of human pancreatic exocrine cells towards beta cells would offer a major advantage by providing an abundant and autologous source of beta cells. Over the past d...
متن کاملSkin Dosimetry of Some Beta Sources using the VARSKIN2 Code
Introduction: Skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using VARSKIN2. Materials and Methods: In this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90Sr/90Y, 147Pm, 32P beta emitter radioisotopes by using input parameters: activity of source, ...
متن کاملGeneration of Functional Beta-Like Cells from Human Exocrine Pancreas
Transcription factor mediated lineage reprogramming of human pancreatic exocrine tissue could conceivably provide an unlimited supply of islets for transplantation in the treatment of diabetes. Exocrine tissue can be efficiently reprogrammed to islet-like cells using a cocktail of transcription factors: Pdx1, Ngn3, MafA and Pax4 in combination with growth factors. We show here that overexpressi...
متن کاملLight sources inside photonic crystals
We have measured the optical fluorescence spectra of dye incorporated in high-quality photonic crystals made from colloids. The spectra reveal a stopgap that is due to Bragg reflection with strikingly reduced attenuation compared with plane-wave transmission. The modified attenuation is independent of the position of the sources in the sample and is brought about by diffuse scattering from defe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetologia
سال: 2016
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-016-3879-6